GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs9876781 | 1 | rs6804774 | chr3:48430617 | ATRIP | chr3:48488141-48507708:+ | 0.17 | 3.81 | 0.000155 | Longevity |
| THCA | cis | rs9876781 | 1 | rs6804774 | chr3:48430617 | TREX1 | chr3:48501186-48509043:+ | -0.26 | -5.97 | 4.57E-9 | Longevity |
| THCA | cis | rs6805251 | 1 | rs6805251 | chr3:119560606 | GSK3B | chr3:119540804-119813264:- | 0.14 | 4.81 | 2.02E-6 | HDL cholesterol |
| THCA | cis | rs73201462 | 1 | rs6805582 | chr3:128029008 | EEFSEC | chr3:127872313-128127488:+ | -0.2 | -3.52 | 0.000478 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs7647973 | 1 | rs6805609 | chr3:49471522 | GMPPB | chr3:49758932-49761384:- | 0.17 | 3.96 | 8.54E-5 | Menarche (age at onset) |
| THCA | cis | rs7647973 | 1 | rs6805609 | chr3:49471522 | P4HTM | chr3:49027341-49044579:+ | -0.15 | -3.84 | 0.000139 | Menarche (age at onset) |
| THCA | cis | rs73201462 | 1 | rs6805621 | chr3:128029204 | EEFSEC | chr3:127872313-128127488:+ | -0.2 | -3.52 | 0.000478 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs9815354 | 1 | rs6805880 | chr3:41865397 | ULK4 | chr3:41288091-42003660:- | 1.04 | 19.1 | 7.17E-61 | Diastolic blood pressure |
| THCA | cis | rs10935120 | 1 | rs6806417 | chr3:134211446 | ANAPC13 | chr3:134196547-134204865:- | -0.38 | -12.22 | 4.36E-30 | Height |
| THCA | cis | rs10935120 | 1 | rs6806417 | chr3:134211446 | CEP63 | chr3:134204575-134293852:+ | -0.29 | -6.32 | 5.92E-10 | Height |
| THCA | cis | rs1171113 | 1 | rs680668 | chr6:84229366 | SNAP91 | chr6:84262607-84419127:- | -0.18 | -3.71 | 0.000232 | Bipolar disorder with mood-incongruent psychosis |
| THCA | cis | rs1552244 | 1 | rs68067759 | chr3:10150535 | C3orf10 | chr3:10157333-10168873:+ | -0.21 | -4.45 | 1.05E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs68067759 | chr3:10150535 | VHL | chr3:10183319-10193744:+ | -0.19 | -4.48 | 9.4E-6 | Alzheimer's disease |
| THCA | cis | rs9815354 | 1 | rs6807015 | chr3:41754514 | ULK4 | chr3:41288091-42003660:- | 1.04 | 18.5 | 5.28E-58 | Diastolic blood pressure |
| THCA | cis | rs1847202 | 1 | rs6807627 | chr3:72939767 | GXYLT2 | chr3:72937385-73024520:+ | 0.26 | 5.6 | 3.68E-8 | Motion sickness |